MOLECULAR DIAGNOSTICS • LABORATORY MEDICINE
Japheth Mdenyo
Molecular Diagnostics | Analytical Method Validation | Infectious Disease Diagnostics | Clinical Laboratory Medicine
oscarmdenyo@gmail.com • LinkedIn • oscarmdenyo.com
Professional Profile
Clinical laboratory and molecular diagnostics professional with more than 10 years of progressive experience spanning multidisciplinary diagnostic testing, laboratory leadership, molecular diagnostics, analytical method validation, quality management systems, specimen processing, and patient-facing diagnostic services. M.S. in Laboratory Medicine from the University of Washington, with graduate research focused on analytical validation of dried blood spot Plasmodium 18S rRNA RT-PCR on the Roche cobas automated molecular diagnostic platform.
Core Expertise
- Molecular diagnostics and RT-PCR principles
- Analytical method validation
- Linearity, LoD, precision, accuracy, carryover
- Dried blood spot workflows
- ISO 15189 quality systems
- Clinical laboratory operations
- QC/QA, SOPs, audits, competency
- Pre-analytical quality and specimen integrity
Professional Experience
Patient-facing phlebotomy, specimen processing, Epic/Beaker workflows, pre-analytical quality, point-of-care testing, quality control, and staff mentoring.
Analytical method validation of a modified Plasmodium 18S rRNA RT-PCR workflow using the Roche cobas automated molecular diagnostic platform.
Directed multidisciplinary clinical laboratory operations, ISO 15189 quality activities, staff supervision, validation/verification, procurement, equipment management, and continuous quality improvement.
Supported multidisciplinary laboratory operations, biosafety, audits, quality-control review, staff training, and accreditation readiness.
Multidisciplinary diagnostic testing, phlebotomy, microbiology, infectious-disease testing, quality control, and specimen processing.
Research
Method Validation for Dried Blood Spot Plasmodium 18S rRNA RT-PCR on the Roche cobas Automated Molecular Diagnostic Platform
University of Washington M.S. thesis research adapting the cobas malaria assay for 50 µL whole-blood and DBS specimens and evaluating quantitative performance using standard curves. Validation work included linearity, analytical sensitivity / LoD, precision, accuracy / bias, carryover, DBS stability, matrix matching, and extraction / elution performance.
Education
Selected Presentations
Laboratory Medicine Clinical Research Conference — University of Washington, 2024 and 2025.
Master’s Thesis Defense — University of Washington, May 2025.
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